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Dendrimers as anti-inflammatory agents BJPS
Avti,Pramod K.; Kakkar,Ashok.
Dendrimers constitute an intriguing class of macromolecules which find applications in a variety of areas including biology. These hyperbranched macromolecules with tailored backbone and surface groups have been extensively investigated as nanocarriers for gene and drug delivery, by molecular encapsulation or covalent conjugation. Dendrimers have provided an excellent platform to develop multivalent and multifunctional nanoconjugates incorporating a variety of functional groups including drugs which are known to be anti-inflammatory agents. Recently, dendrimers have been shown to possess anti-inflammatory properties themselves. This unexpected and intriguing discovery has provided an additional impetus in designing novel active pharmaceutical agents. In...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dendrimers; Nanocarriers; Anti-inflammatory agents; Cyclooxygenase (COX-2); Inducible nitric oxide synthase (iNOS); Pro-inflammatory cytokines.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000700006
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Developments in the use of nanocapsules in oncology BJMBR
Yurgel,V.; Collares,T.; Seixas,F..
The application of nanotechnology to medicine can provide important benefits, especially in oncology, a fact that has resulted in the emergence of a new field called Nanooncology. Nanoparticles can be engineered to incorporate a wide variety of chemotherapeutic or diagnostic agents. A nanocapsule is a vesicular system that exhibits a typical core-shell structure in which active molecules are confined to a reservoir or within a cavity that is surrounded by a polymer membrane or coating. Delivery systems based on nanocapsules are usually transported to a targeted tumor site and then release their contents upon change in environmental conditions. An effective delivery of the therapeutic agent to the tumor site and to the infiltrating tumor cells is difficult...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nanotechnology; Nanocapsules; Nanocarriers; Cancer.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000600486
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